InterPAD - DETAILS

635324-72-0, CTLA-4 inhibitor, Ctla-4 - inhibitor, 2-(4-Fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one, CTLA-4-inhibitor, B7/CD28 interaction inhibitor 1, VC-24720, 4-(4-fluorophenyl)-10-methyl-7-[3-(trifluoromethyl)phenyl]-3,4,8,10,11-pentazatricyclo[7.3.0.02,6]dodeca-1,6,8,11-tetraen-5-one, CTLA-4 inhibitor?, CTLA-4 inhibitor 1, SCHEMBL23860573, C21H13F4N5O, EX-A913, BCP16856, MFCD28127008, AKOS027439956, BS-17357, HY-102090, CS-0022985, FT-0696799, ABM-24720;B7/CD28 interaction inhibitor 1, N11420, A914724, J-690337, 2-(4-fluorophenyl)-1,6-dihydro-6-methyl-4-[3-(trifluoromethyl)phenyl]dipyrazolo[3,4-b:3',4'-d]pyridin-3(2H)-one, 2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,6-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(2H)-one, 4-(4-fluorophenyl)-10-methyl-7-[3-(trifluoromethyl)phenyl]-3,4,8,10,11-pentaazatricyclo[7.3.0.0(2),?]dodeca-1(9),2(6),7,11-tetraen-5-one, 4-(4-fluorophenyl)-10-methyl-7-[3-(trifluoromethyl)phenyl]-3,4,8,10,11-pentazatricyclo[7.3.0.0^{2,6]dodeca-1,6,8,11-tetraen-5-one, 4-{6-[(1E,2E)-2-(3-Methylbenzylidene)hydrazino]-2-[2-(2-pyridinyl)ethoxy]-4-pyrimidinyl}morpholine methanesulfonate

No.	Title	Href
1	Cordycepin synergizes with CTLA-4 blockade to remodel the tumor microenvironment for enhanced cancer immunotherapy. Int Immunopharmacol. 2023 Nov;124(Pt A):110786. doi: 10.1016/j.intimp.2023.110786.	`Click`

No.

Title

Href

Cordycepin synergizes with CTLA-4 blockade to remodel the tumor microenvironment for enhanced cancer immunotherapy. Int Immunopharmacol. 2023 Nov;124(Pt A):110786. doi: 10.1016/j.intimp.2023.110786.

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Name	Anti-CTLA-4 antibody
PubChem CID	101136468
Molecular Weight	427.4g/mol
Synonyms	635324-72-0, CTLA-4 inhibitor, Ctla-4 - inhibitor, 2-(4-Fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one, CTLA-4-inhibitor, B7/CD28 interaction inhibitor 1, VC-24720, 4-(4-fluorophenyl)-10-methyl-7-[3-(trifluoromethyl)phenyl]-3,4,8,10,11-pentazatricyclo[7.3.0.02,6]dodeca-1,6,8,11-tetraen-5-one, CTLA-4 inhibitor?, CTLA-4 inhibitor 1, SCHEMBL23860573, C21H13F4N5O, EX-A913, BCP16856, MFCD28127008, AKOS027439956, BS-17357, HY-102090, CS-0022985, FT-0696799, ABM-24720;B7/CD28 interaction inhibitor 1, N11420, A914724, J-690337, 2-(4-fluorophenyl)-1,6-dihydro-6-methyl-4-[3-(trifluoromethyl)phenyl]dipyrazolo[3,4-b:3',4'-d]pyridin-3(2H)-one, 2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,6-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(2H)-one, 4-(4-fluorophenyl)-10-methyl-7-[3-(trifluoromethyl)phenyl]-3,4,8,10,11-pentaazatricyclo[7.3.0.0(2),?]dodeca-1(9),2(6),7,11-tetraen-5-one, 4-(4-fluorophenyl)-10-methyl-7-[3-(trifluoromethyl)phenyl]-3,4,8,10,11-pentazatricyclo[7.3.0.0^{2,6]dodeca-1,6,8,11-tetraen-5-one, 4-{6-[(1E,2E)-2-(3-Methylbenzylidene)hydrazino]-2-[2-(2-pyridinyl)ethoxy]-4-pyrimidinyl}morpholine methanesulfonate
Drug Type	Antibody
Formula	C₂₁H₁₃F₄N₅O
SMILES	CN1C2=NC(=C3C(=C2C=N1)NN(C3=O)C4=CC=C(C=C4)F)C5=CC(=CC=C5)C(F)(F)F
InChI	1S/C21H13F4N5O/c1-29-19-15(10-26-29)18-16(20(31)30(28-18)14-7-5-13(22)6-8-14)17(27-19)11-3-2-4-12(9-11)21(23,24)25/h2-10,28H,1H3
InChIKey	WQKVVTLTCHDAST-UHFFFAOYSA-N
Toxicity	Organism	Test Type	Route(Dose)
Structure			Download 2D MOL 3D MOL

Pair Name	Cordycepin, Anti-CTLA-4 antibody
Partner Name	Cordycepin
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Biological Phenomena	Induction-->Immunomodulatory
In Vitro Model	MC-38	Mouse colon adenocarcinoma	Mus musculus (Mouse)	CVCL_B288
	CT26	Mouse colon adenocarcinoma	Mus musculus (Mouse)	CVCL_7254
In Vivo Model	1×10⁶ MC38 cells in 100 µL of PBS and injected them subcutaneously (s.c.) into the right flank of C57BL/6J mice. In a similar manner, we injected 1×10⁶ CT26 cells, also suspended in 100 µL of PBS, s.c. into the right flank of Balb/c mice.
Result	Our current study successfully established a combination therapeutic strategy utilizing cordycepin and CTLA-4 blockade. This strategy demonstrated a significant synergistic effect against cancer, highlighting its importance in cancer treatment.